Accelerating Breakthrough Discoveries into Medicines

Jean Tang, MD, PhD

Jean Tang, MD, PhD

Stanford University, Stanford, Calif.

Dr. Tang is developing a topical ointment for basal cell carcinoma prevention and treatment.

Jean Tang, MD, PhD, is an Associate Professor of Dermatology at Stanford University Medical Center.

The Tang laboratory focuses on discovering new way to treat and prevent basal cell carcinoma (BCC) and bring laboratory-based insights to the benefit of patients.

Dr. Tang and her team are interested in the use of small molecule inhibitors to treat and prevent BCC. The lab has launched an investigator-initiated randomized clinical trial testing GDC-0449 (Genentech) for BCC prevention in patients with basal cell nevus syndrome (with Ervin Epstein). GDC-0449 is a new inhibitor of the Hedgehog signaling pathway that drives BCC development. The lab also is testing itraconazole, an antifungal drug, for inhibition of BCC biomarkers in a Phase II Pilot study in patients with sporadic BCC tumors (with Philip Beachy).

The team also is interested in using large cohorts and datasets to understand risk factors for non-melanoma skin cancer and melanoma development. By utilizing data from several large population studies, they have determined that vitamin D levels correlate with skin cancer risk in humans. In the lab, they have determined that vitamin D can prevent tumors in mice.

Dr. Tang’s research interests extend to early detection using fluorescence-based imaging techniques to identify sub-clinical, microscopic tumors and the relationship between sunlight, vitamin D, and skin cancer risk.

Dr. Tang earned her medical degree and doctorate in Biophysics from Stanford University, Stanford, Calif. She served a residency in Dermatology at Stanford University Hospital and Clinics and a research fellowship and a fellowship in Epidemiology and Statistics at University of California –San Francisco.

Dates to Know

April 5, 2017
Letter of Intent Deadline

May 31, 2017
Full Application Deadline (For those invited)

December 2017
Awardees Notified

Harrington Project

The Harrington Discovery Institute is the nonprofit arm of the Harrington Project for Discovery & Development, an international initiative supporting breakthrough research by physician-scientists. The Project is a new and powerful approach to address some of the challenges hindering advancement of medicine today.

The Harrington Grant is an important part of the overall pharmaceutical research initiative created by The Harrington Project.

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