Accelerating Breakthrough Discoveries into Medicines

Wolfgang Bernhard Liedtke, MD, PhD

Wolfgang Bernhard Liedtke, MD, PhD

Wolfgang Bernhard Liedtke, MD, PhD, is an Associate Professor in the Center for Translational Neuroscience Medicine in the Division of Neurology at Duke University, Durham, NC, and a neurologist and neuroscience-physiology researcher.

Dr. Liedtke’s research is centered on calcium signaling and transient receptor potential (TRP) ion channels. His laboratory is deconstructing sensing mechanisms at the molecular, cellular, organ/systems and organismal level, specifically focusing on osmotic and mechanical stimuli as highly relevant sensory cues. He established his own pain clinics dedicated to patients suffering from trigeminal nerve pain, particularly trigeminal neuralgia and trigeminal neuropathic pain. His latest research is looking into the development of a new class of drugs that inhibit the pain response in skin, with potential applications in painful skin conditions, including sunburn and wound pain. He is developing treatments that will target TRP ion channels for treatment of chronic pain. This work will pave the way for translational-medical use and will benefit Dr. Liedtke’s patients suffering from therapy-refractory pain syndromes.

Dr. Liedtke earned his medical degree from the University of Cologne, Germany, and his PhD from the University of Bochum, Germany. His residency in neurology and psychiatry at Eberhard Karls Universitat Tubingen and University of Duisburg-Essen, both in Germany led to a fellowship in neuropathology at the Albert Einstein College of Medicine, New York. He was awarded the Ebert Clinical Scholar of the Klingenstein Fund in New York City and was recently named the Ruth K. Broad Duke Neuroscience Faculty Scholar.

His work has earned him several research awards, including National Institutes of Health grants, the Komen for the Cure Foundation, two Duke Institute for Brain Sciences Incubator awards, a collaborative funding grant from the North Carolina Biotech Center and a Collaborative Innovator Award of the Duke Institute for Genome Sciences & Policy. He has published his work in Cell, Neuron, Annals of Neurology, the Journal of Neuroscience, Environmental Health Perspectives and Proceedings of the National Academy of Sciences.

Harrington Project

The Harrington Discovery Institute is the nonprofit arm of the Harrington Project for Discovery & Development, an international initiative supporting breakthrough research by physician-scientists. The Project is a new and powerful approach to address some of the challenges hindering advancement of medicine today.

The Harrington Grant is an important part of the overall pharmaceutical research initiative created by The Harrington Project.