Accelerating Breakthrough Discoveries into Medicines

Roger A. Greenberg, MD, PhD

Roger A. Greenberg, MD, PhD

Roger A. Greenberg, MD, PhD, is an Associate Professor in the Department of Cancer Biology and an Associate Investigator in the Abramson Family Cancer Research Institute in the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. He is also the Director of Basic Science at the Basser Center for BRCA there.

Dr. Greenberg’s laboratory is focusing on the development of a new class of anti-cancer drugs for breast and ovarian cancers through a novel drug screening technology. He is interested in the BRCA1-dependent signaling pathways that are necessary to repair DNA double strand breaks and suppress breast and ovarian cancers. His basic findings have led to the identification of three new breast cancer susceptibility genes and have suggested novel strategies to treat BRCA mutated cancers. His work also has led to new paradigms for DNA damage recognition and communication between DNA change response and transcription. His research suggests that targeting specific ubiquitin-related pathways in DNA repair dysfunctional cancer cells is a promising new approach to cancer chemotherapy.

Dr. Greenberg began his career as a medicinal chemist with DuPont-Merck Pharmaceuticals, designing and synthesizing HIV protease inhibitors. He earned his medical and doctorate degrees from The Albert Einstein College of Medicine, New York, and completed his residency in clinical pathology at Brigham and Women’s Hospital, Boston. He served a postdoctoral fellowship at the Dana-Farber Cancer Institute, also in Boston, where his research contributed to a developing concept of a BRCA1-centered breast and ovarian tumor suppressor network.

Dr. Greenberg is a Diplomat of the American Board of Pathology and a newly elected member of the American Society of Clinical Investigation. He is published numerous peer-reviewed publications, including Cell, Nature, Science, Nature Structural & Molecular Biology, Science Translational Medicine, The Journal of Cell Biology, The Journal of Clinical Investigation, Genes & Development and The Proceedings of the National Academy of Sciences.

Harrington Project

The Harrington Discovery Institute is the nonprofit arm of the Harrington Project for Discovery & Development, an international initiative supporting breakthrough research by physician-scientists. The Project is a new and powerful approach to address some of the challenges hindering advancement of medicine today.

The Harrington Grant is an important part of the overall pharmaceutical research initiative created by The Harrington Project.