Accelerating Breakthrough Discoveries into Medicines

David Ginsburg, MD

James V. Neel Distinguished University Professor of Internal Medicine and Human Genetics; Warner-Lambert/Parke-Davis Professor of Medicine; Member of the Life Sciences Institute at the University of Michigan Medical School; Howard Hughes Medical Institute Investigator

Dr. Ginsburg obtained his bachelor’s degree in molecular biophysics and biochemistry from Yale University, New Haven, CT He earned his MD from Duke University, Durham, NC, and competed postdoctoral work as a hematology fellow at Harvard University, Cambridge, MA. During his fellowship, Dr. Ginsburg cloned the gene for von Willebrand factor, one of the proteins that are critical to the cascade of reactions that causes blood to clot. Dr. Ginsburg continued investigating blood clotting and disturbances of it in a lab that he launched at the University of Michigan, Ann Arbor, MI.

At the University of Michigan, Dr. Ginsburg identified subtypes of von Willebrand disease and other clotting conditions. He discovered the genes responsible for combined deficiency of factors V and VIII (LMAN1, MCFD2) and thrombotic thrombocytopenic purpura, (ADAMTS13). The attempt to explain variations in the severity of these disorders led him to look for modifier genes that might account for disparities in these clotting factor diseases, in part by performing genome-wide studies to search for common clotting factor gene variations. His lab also has examined the role of plasminogen activators, proteins that turn on the fibrinolytic system, the body’s mechanism for dissolving blood clots. Dr. Ginsburg’s ongoing research over the last 25 years has contributed significantly to our understanding of the clotting system and the characterization of coagulation diseases that afflict millions of people.

Dr. Ginsburg is a member of the Institute of Medicine, the National Academy of Sciences, the Association for American Physicians, the American Society for Clinical Investigation (ASCI) and the American Academy of Arts & Sciences. He is the recipient of numerous awards, including the Pasarow Cardiovascular Research Award, the Distinguished Scientist Award (American Heart Association), the Stanley J. Korsmeyer Award (ASCI), the E. Donnell Thomas Lecture & Award (American Society of Hematology) and the Distinguished Research in Biomedical Sciences Award (Association of American Medical Colleges). He is board certified in internal medicine, oncology, hematology and genetics.