Clinical Trial: The Cancer of the Pancreas Screening-5 (CAPS5) Study

Purpose of Study:

Pancreatic cancer is a deadly disease. Currently, most patients present with advanced stage disease. The best hope for improving survival is early detection because patients whose cancers are diagnosed at an early stage have better outcomes. The deadly nature of pancreatic cancer has led to efforts to screen individuals with an inherited predisposition to pancreatic cancer. Screening to detect pancreatic cancer precursors is likely to be an effective way to reduce pancreatic cancer mortality.

The goal of this study is to evaluate two different biomarkers for their potential usefulness in identifying evidence of pancreatic cancers before patients present with symptoms. A biomarker is a molecule that is found in body fluids like blood or pancreatic juice. Its presence can be a sign of a normal or abnormal condition or process occurring in the body.

Protocol Summary:

In this study, University Hospitals Cleveland Medical Center is joining a consortium of eight tertiary medical centers led by Johns Hopkins University. Patients scheduled for endoscopic examinations of their pancreases as part of their normal standard of care can participate in the study. Patients may be having these procedures because they are considered to be at high risk for developing pancreatic cancer or they may be having these procedures for other medical reasons.

Study participants will be asked to:

  • Complete a questionnaire about family history and personal medical history;
  • Give a blood sample;
  • Allow us to collect a sample of pancreatic juice during their endoscopic procedure.

If they have been recommended to have ongoing screening and surveillance, participants may be asked to remain in the study for up to 5 years

Site Locations:

UH Cleveland Medical Center
UH Ahuja Medical Center

Contact:

Nancy Furey
(216) 844-7314
nancy.furey@uhhospitals.org

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