Clinical Research & Clinical Trials

Department of Radiation Oncology Offers Advanced Clinical Research and Clinical Trials

Improvements to patient care, stronger treatment outcomes and improvements to quality of life during treatments are at the core of our research at the Department of Radiation Oncology at University Hospitals Seidman Cancer Center in Cleveland, Ohio. Our doctors offer national and international expertise in all phases of advanced clinical trials, including:

  • Phase 1: Investigational (experimental), leading-edge trials with 15 to 30 participants
  • Phase 2: Trials that test the effect of new treatments on a certain cancer or the body with fewer than 100 participants
  • Phase 3: National clinical trials that compare a new treatment (or new use of a treatment) with the current standard treatment with 100 to thousands of participants
  • Phase 4: Trials that assess the long-term safety and effectiveness of a new treatment with several hundred to several thousand participants

International Leadership in Research Organizations

Physician researchers in the Department of Radiation Oncology hold leadership positions with national and international research organizations such as the Eastern Cooperative Oncology Group (ECOG), Radiation Therapy Oncology Group (RTOG), Gynecologic Oncology Group (GOG) and the American College of Radiology Imaging Network (ACRIN).

Our radiation oncology experts continue to direct the research frontier as they plan the next phase of research and clinical trials. With this strong national research presence, our physician researchers are able to bring new therapies and advanced medicine to patients at UH.

National Clinical Trial Leadership for Head and Neck Cancer

Mitchell Machtay, MD, the Chairman of the Department of Radiation Oncology, leads a national Phase 3 randomized clinical trial studying the effect of Cetuximab, a chemotherapy drug, with intensity modulated radiation therapy.

This study is for people with head/neck cancer who have had surgery but still need radiation. The trial will continue for several years with the national goal of 700 participants.

For more clinical trial information, please view our general clinical trial information page.

CyberKnife® Radiosurgery Studies

The Department of Radiation Oncology at UH has a number of ongoing studies involving CyberKnife® for different types of cancer, including:

We encourage study participation for all patients who meet the criteria. This participation is voluntary and is overseen by University Hospitals Internal Review Board (IRB).

For more information about specific clinical trials at UH, please search our database of current clinical trials. For research or clinical trial questions, we also provide a clinical trial nurse on call from 9 a.m. to 5 p.m. to answer your questions or discuss our clinical trial process. To reach the nurse, please call 800-641-2422.

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