A pleural biopsy is a procedure to remove a sample of the tissue lining the lungs and the inside of the chest wall to check for disease or infection.

This test does not have to be done in the hospital. It may be done at a clinic or doctor's office.

You will be sitting up for the biopsy. The health care provider will cleanse the skin at the biopsy site, and inject a local numbing drug (anesthetic) through the skin and into the lining of the lungs and chest wall (pleural membrane).

A larger, hollow needle is then placed through the skin and into the chest cavity. The doctor rotates the needle. At various times during the procedure, you will be asked to sing, hum, or say "eee." This helps prevent air from getting into the chest cavity, which can cause a lung collapse (pneumothorax).

The doctor removes the needle to collect tissue samples. Usually, 3 biopsy samples are taken. When the test is completed, a bandage is placed over the biopsy site.

You will have blood tests before the biopsy, and you may have a chest x-ray taken. You must sign consent forms.

With the injection of the local anesthetic, you may feel a brief prick and a burning sensation. When the biopsy needle is inserted, you may feel pressure. As the needle is being removed, you may feel a tugging sensation.

Pleural biopsy is usually done to determine the cause of a collection of fluid around the lung (persistent pleural effusion) or other abnormality of the pleural membrane. Pleural biopsy can diagnose tuberculosis, cancer, and other diseases.

The pleural tissues appear normal, without signs of inflammation, infection, or cancer.

Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

Abnormal results may reveal cancer, tuberculosis, a viral disease, a fungal disease, a parasitic disease, or collagen vascular disease.

Other conditions under which the test may be done include:

• Metastatic pleural tumor
• Primary lung cancer

There is a slight chance of the needle puncturing the wall of the lung, which can partially collapse the lung. This usually gets better on its own. There is a chance of excessive blood loss.

If a closed pleural biopsy is not enough to make a diagnosis, you may need a surgical biopsy of the pleura.

Mason RJ, Murray J, Broaddus VC, Nadel JA. Textbook of Respiratory Medicine. 4th ed. Philadelphia, Pa: WB Saunders; 2005.

Noble J. Textbook of Primary Care Medicine. 3rd ed. St. Louis, Mo: Mosby; 2001:725.