Clinical Research

Research Aimed at Directly Benefiting Our Pediatric Orthopedic Patients

The Division of Pediatric Orthopedic Surgery at University Hospitals Rainbow Babies & Children’s Hospital has a history of developing new therapies and new techniques that goes back more than 100 years. We are participating in almost 100 studies approved by the Institutional Review Board. This board reviews research involving individuals for safety and ethical considerations.

Clinical researchers at the Division of Pediatric Orthopedic Surgery:

  • Developed spinal cord monitoring, a system used around the world to help make spine surgery safer
  • Developed a revolutionary “growing rod” program so that very young children with spine deformities can have a much better chance of growing to a normal height with their organs developing more fully
  • Pioneered the use of Amicar®, a medication that helps reduce blood loss and the possibility of complications in patients undergoing spinal surgery
  • Revolutionized the less invasive anterior approach to spinal surgery, which involves operating through the chest rather than from the back; it is used to improve mobility of the spine and guide spinal growth
  • Currently developing treatment methods for limb deformity using complex surgical innovations
  • Analyzing forensic samples to better understand pediatric anatomy and injury, as well as develop safer ways to treat orthopedic problems in children
  • Participating in multicenter analyses of neuromuscular disorders
  • Participated in developing ScoliScore, a painless and noninvasive tool to help predict the progression of scoliosis

Bone Tumor Research

The Division of Pediatric Orthopedic Surgery conducts both clinical and basic scientific research to study bone tumors. We have recently published articles on the molecular biology of bone tumors and their treatment. In addition, we are currently evaluating the treatment of some benign bone tumors.

Scoliosis Treatment in Children and Advanced Spine Techniques

Our division has provided some of the landmark studies that affect how we treat scoliosis and other spinal deformities. We have participated in the development of advanced evaluation and surgical techniques. We continue to advance scoliosis treatment by participating in leading-edge research and advanced spine surgery.

Largest Pediatrics Orthopedic and Spinal Deformity Database in the U.S.

Our database of treatments and patient outcomes is one of the most comprehensive in the country. In addition, we participate in national databases for spinal deformity, early onset scoliosis, and Legg-Calve-Perthes disease. Our database allows us to follow our patients better, gather information about trends and outcomes, and provide evidence for many of the treatments of pediatric orthopedic conditions. Armed with such valuable information, we can aggressively pursue our longtime passion for evidence-based medicine and continually work to identify the best possible treatments.

Treatment of Scoliosis Without Fusion Treatment

UH Rainbow Babies & Children’s Hospital and University Hospitals Cleveland Medical Center, along with SpineForm LLC, Cincinnati Children's Hospital Medical Center, Reynolds Consulting, and E-Prime Group, have been awarded almost $1 million for a clinical study of an idiopathic scoliosis growth modulation system known as the HemiBridge™ System. This small plate and screw system, inserted into the spine using a minimally invasive approach, addresses the need for nonfusion treatment of scoliosis curves that are worsening. This device guides the growth of the spine and is expected to allow children to maintain their activity levels while correcting scoliosis curves, without the need to wear a brace.

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