Angie’s Institute

Stem Cell & Bone Marrow Transplant Center

The Pediatric Stem Cell & Bone Marrow Transplant Center Offers Hope and Help for Kids

For children and young adults who need a bone marrow transplant, there is no better place than University Hospitals Rainbow Babies & Children’s Hospital’s Angie Fowler Adolescent & Young Adult Cancer Institute and UH Seidman Cancer Center in Cleveland, Ohio. Our experienced pediatric program includes longstanding accreditation from the Foundation for the Accreditation of Cellular Therapy (FACT) and is one of the nation’s premier programs for children, adolescents and young adults with malignant and non-malignant disorders. The program offers comprehensive services, including:

  • Pre-transplant assessment
  • Donor selection options and evaluation
  • Parent and patient education
  • Psychosocial services
  • Comprehensive follow-up care and monitoring

Conditions Treated

Our treatments provide the best chance of survival for a variety of childhood cancers and other serious disorders, including:

  • Bone marrow failure syndromes, including aplastic anemias
  • Hematopoietic malignancies
  • Hemoglobinopathies (sickle cell disease, thalassemia and others)
  • Autoimmune syndromes
  • Metabolic diseases
  • Solid tumors
  • Transplantable disorders after abnormal newborn screenings

Advanced Treatments and Transplant Services

Blood and bone marrow transplants at UH Rainbow Babies & Children’s Hospital are performed with both related and unrelated donors. The transplant program utilizes numerous cord blood banks that are available nationally and internationally.

Treatment options include:

  • Matched related donor transplant – a sibling who has the same bone marrow type and the same parents. Siblings are matched through human leukocyte antigen (HLA) typing blood tests.
  • Matched unrelated donor transplant – volunteers who have the same bone marrow type as the patient. These donors are found through national organizations that match donors and patients who have the same type of bone marrow.
  • Haplo-identical transplants – “half” matched family members (often a parent). The use of haplo-identical transplants from a close relative greatly expands the potential donor pool, making more patients eligible for the transplant.
  • Haplo-identical transplant with umbilical cord blood transplant
  • Single and double umbilical cord blood transplant

Nationally and Internationally Recognized Experts

Consistently ranked among the best children’s hospitals in the nation by U.S. News & World Report, UH Rainbow Babies & Children’s Hospital provides families with access to world-renowned physicians who become the patient’s partners in care for life. Our highly experienced team has seen the number of transplants performed by the blood and bone marrow transplant (BMT) specialists more than double since 2008.

Our nationally and internationally renowned physicians, clinical researchers and educators, and a dedicated, compassionate team of pediatric specialists collaborate to help improve the lives of infants, children, teenagers and young adults.

Multidisciplinary Team Approach

At Angie’s Institute, a unified team of board-certified pediatric physicians and specialists manage the child’s bone marrow or stem cell transplant and work side by side with the family to create an individualized treatment plan for each patient. Our multidisciplinary team includes:

  • Specialists in stem cell therapies and bone marrow transplant
  • Oncologists
  • Nurses
  • Psychologists
  • Social workers
  • Child life specialists
  • Supportive care personnel
  • Specialists in transplant-related complications

In addition, our team collaborates with the nationally recognized adult BMT program at UH Seidman Cancer Center to offer young patients access to leading-edge protocols and novel therapies not available at other area centers. And, through our relationships with the Case Comprehensive Cancer Center, we provide access to lifesaving pediatric and adult clinical trials.

Inpatient and Outpatient Convenience

Patients receive inpatient care in a 30-bed high efficiency particulate air (HEPA)-filtered unit designed for the needs of those with weakened immune systems. For the convenience of our young patients, we also offer a comprehensive outpatient program. Patients may receive chemotherapy infusions, blood component transfusions, stem cell infusions and extensive evaluations without having to be admitted to the hospital.

Superior Follow-Up Care

The Pediatric Stem Cell & Bone Marrow Transplant Program offers extraordinary outcomes. Our 100-day patient survival rate for bone marrow transplant patients exceeds 96 percent. Working closely with highly trained sub-specialists, our team’s proficiency ensures the highest level of expertise for transplant complications through our dedicated transplant survivorship program.

Because transplant success depends greatly on patient care delivered in the weeks, months and years after the transplant, our specialized team at UH Rainbow Babies & Children’s Hospital provides compassionate and comprehensive follow-up care, with the ultimate goal of returning patients to their normal lifestyles.

Request Information

For more information about the Pediatric Blood & Marrow Transplant Center, call 216-844-5437.