• Director, Adult Sickle Cell Anemia Center, UH Case Medical Center
  • Associate Professor, Medicine, CWRU School of Medicine



Jane Little, MD, is a hematology/oncology specialist at University Hospitals Seidman Cancer Center. Hematology is the study of diseases of the blood and of blood-forming organs and oncology is the study of cancer. Dr. Little is an Associate Professor of Medicine at Case Western Reserve University School of Medicine.

Dr. Little is board-certified in internal medicine, hematology and medical oncology and fellowship trained in hematology/oncology. Her special clinical interests include benign (non-cancerous) blood diseases, primarily sickle cell disease, and bone marrow transplantation. Dr. Little was appointed Director of the Adult Sickle Cell Disease Program at UH Seidman Cancer Center in 2011. Prior to joining University Hospitals, she served as an attending physician and hematology consultant at Albert Einstein College of Medicine in the Bronx, New York.

Dr. Little graduated magna cum laude with a bachelor’s degree in history from Case Western Reserve University. She remained in Cleveland and attended Case Western Reserve University School of Medicine to earn her Doctor of Medicine. She completed a residency in internal medicine at the University of Iowa, Iowa City, Iowa and remained in Iowa to complete clinical and research fellowships in hematology/oncology. She subsequently worked at the University of Minnesota and the National Institutes of Health.

Dr. Little currently sits on editorial review boards, national and regional committees and administrative boards related to her field. She is also an accomplished lecturer at local and national seminars related to sickle cell disease and general hematology/oncology topics.

Professional memberships

Dr. Little is a member of the American Federation of Medical Research and the American Society of Hematology.

Board Certifications

American Board of Internal Medicine - Internal Medicine
American Board of Internal Medicine - Hematology
American Board of Internal Medicine - Medical Oncology

Education & Training


1979, Case Western Reserve University

Medical / Professional School(s)

1985, Case Western Reserve University School of Medicine


1988, Internal Medicine - University of Iowa Hospitals and Clinics


1990, Hematology/Oncology - University of Iowa Hospitals and Clinics

Research Fellowship

1991, Hematology/Oncology - University of Iowa Hospitals and Clinics


Benign Hematology, Sickle Cell Disease

Awards & Recognition

  • Helen Evans Mid-Career Faculty Development Award, Women Faculty of Case Western Reserve University School of Medicine, 2014

Office Locations

UH Case Medical Center
Department of Medicine-Hematology and Oncology
11100 Euclid Ave
Cleveland, OH 44106
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Research Interests

Dr. Little is an accomplished researcher with a focus on sickle cell disease, its prognosis, and management. She has been the principal investigator on several nationally funded research papers related to her field.

Industry Relationships

University Hospitals is committed to transparency in our interactions with industry partners, such as pharmaceutical, biotech, or medical device companies. At UH, we disclose practitioner and their family members’ ownership and intellectual property rights that are or in the process of being commercialized. In addition, we disclose payments to employed practitioners of $5,000 or more from companies with which the practitioners interact as part of their professional activities. These practitioner-industry relationships assist in developing new drugs, devices and therapies and in providing medical education aimed at improving quality of care and enhancing clinical outcomes. At the same time, UH understands that these relationships may create a conflict of interest. In providing this information, UH desires to assist patients in talking with their practitioners about industry relationships and how those relationships may impact their medical care.

UH practitioners seek advance approval for certain new industry relationships. In addition, practitioners report their industry relationships and activities, as well as those of their immediate family members, to the UH Office of Outside Interests annually. We review these reports and implement management plans, as appropriate, to address conflicts of interest that may arise in connection with medical research, clinical care and purchasing decisions.

View UH’s policy (PDF) on practitioner-industry relationships.

For calendar year 2013, Jane Little, MD did not disclose any Outside Relationships with Industry.