Thrombosis Panel

The Thrombosis Panel includes testing for the C677T mutation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene, prothrombin (Factor II) G20210A mutation analysis and factor V Leiden mutation analysis with reflex to Factor V HR2 if the Factor V Leiden testing is positive. Individuals with multiple thrombophilic mutations develop venous thromboembolism at a younger age and are at higher risk for recurrent thrombosis than those with a single defect.

The panel may be ordered as is or the tests may be ordered individually.

Indications for Testing:

  • Deep vein thrombosis
  • Pulmonary embolism
  • Stroke
  • Superficial venous thrombosis, phlebitis or thrombophlebitis
  • History of thromboembolism
  • Premature cardiovascular disease
  • Peripheral vascular artery disease
  • Acute myocardial infarction
  • Personal history of 2 or more blood-clotting incidents
  • Family history of blood clots, early stroke or premature vascular artery disease
  • Unexplained early-onset severe preeclampsia, placental abruption, or significant intrauterine growth retardation
  • Recurrent unexplained first-trimester losses

Sample Requirements

5 mL whole blood in purple top (EDTA) tube

Sample Handling

Blood samples should be refrigerated or kept cold. Blood samples should never be frozen. Specimens being sent from outside facilities should be packaged according to standard medical safety practices with a cold pack. The specimen should be shipped by overnight priority [scheduled to arrive by Friday AM at the latest].

Shipping Address

Center for Human Genetics Laboratory
10524 Euclid Ave, Sixth Floor
Cleveland, OH 44106
216-983-1134

For local samples, please call the Center for Human Genetics Laboratory (216-983-1134) to arrange for sample pick up.

Turnaround Time

3-9 days

Cost/CPT Codes

total $430.50
Factor V Leiden $114.80/ 81241; MTHFR $200.90/81291; Prothrombin $114.80/81240

Please submit a completed Prenatal and Postnatal Cytogenetics and Molecular specimens requisition (PDF) for each sample.

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Schedule your appointment with a specialist at University Hospitals.
1-866-UH4-CARE (1-866-844-2273)

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