Hearing Loss Panel

The Hearing Loss Panel includes:

The testing panel is performed sequentially in the order listed above, unless specified otherwise. The tests in the panel may also be chosen individually. The Aminoglycoside Induced Deafness m.1555A>G is included in the MTRNR1 Sequence Analysis and is no longer offered as an individual test. Each of these mutations or genes alone or in combination may be responsible for more than 60% of cases of genetic causes hearing loss, specifically non-syndromic autosomal recessive sensorineural hearing loss.

Indications for Testing

  • Failed newborn hearing screen
  • Sensorineural non-syndromic hearing loss
  • Non-syndromic deafness or hearing loss

OMIM #s: 580000, 121011, 604418, 500008

Sample Requirements

  • Infants: 2-3 mL whole blood in purple top EDTA tube
  • Children (>2 years) and Adults: 5-7 mL whole blood in purple top EDTA tube

Sample Handling

Blood samples stored overnight should be refrigerated or kept cold. Blood samples should never be frozen. Specimens being sent from outside facilities should be packaged according to standard medical safety practices with a cold pack. The specimen should be shipped by overnight priority [scheduled to arrive by Friday AM at the latest].

Shipping Address

Center for Human Genetics Laboratory
10524 Euclid Ave, Sixth Floor
Cleveland, OH 44106

For local samples, please call the Center for Human Genetics Laboratory (216-983-1134) to arrange for sample pick-up.

Turnaround Time

14 days

List Price /CPT Codes

  • Connexin 26 Sequence Analysis: $809.09 / 81404
  • Connexin 30 Deletion Testing: $343.18 / 81400
  • Mitochondrial MTRNR1 and MTTS1 Sequence Analysis: $583.35 / 81404
  • Connexin 30 Sequence Analysis: $657.70 / 81404

Please submit a completed Prenatal and Postnatal Cytogenetics and Molecular specimens requisition for each sample.

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1-866-UH4-CARE (1-866-844-2273)

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