The Hearing Loss Panel includes:
The testing panel is performed sequentially in the order listed above, unless specified otherwise. The tests in the panel may also be chosen individually. The Aminoglycoside Induced Deafness m.1555A>G is included in the MTRNR1 Sequence Analysis and is no longer offered as an individual test. Each of these mutations or genes alone or in combination may be responsible for more than 60% of cases of genetic causes hearing loss, specifically non-syndromic autosomal recessive sensorineural hearing loss.
Indications for Testing
- Failed newborn hearing screen
- Sensorineural non-syndromic hearing loss
- Non-syndromic deafness or hearing loss
OMIM #s: 580000; 121011; 604418; 500008
Sample Requirements
- Infants: 2-3 mL whole blood in purple top EDTA tube
- Children (>2 years) and Adults: 5-7 mL whole blood in purple top EDTA tube
Sample Handling: Blood samples stored overnight should be refrigerated or kept cold. Blood samples should never be frozen. Specimens being sent from outside facilities should be packaged with a cold pack according to standard medical safety practices. The specimen should be shipped by overnight priority [scheduled to arrive by Friday AM at the latest].
Shipping Address: Center for Human Genetics Laboratory
10524 Euclid Ave, 6th Floor
Cleveland, OH 44106
216-983-1134
For local samples, please call the Center for Human Genetics Laboratory (216-983-1134) to arrange for sample pick-up.
Turn Around Time: 14 days
List Price /CPT codes:
$14.35 / 83890 – DNA isolation/extraction, one charge per panel
- Connexin 26 Sequence Analysis $809.09 / 83898 (x5), 83904 (x4), 83909 (x4), 83912
- Connexin 30 Deletion Testing $343.18 / 83894, 83900 (x2), 83901, 83912
- Mitochondrial MTRNR1 and MTTS1 Sequence Analysis $583.35 / 83891, 83898 (x3), 83894 (x3), 83904 (x6), 83909 (x6), 83912
- Connexin 30 Sequence Analysis $657.70 / 83898 (x2), 83894 (x2), 83904 (x4), 83909 (x4), 83912