The Thrombosis Panel includes testing for the C677T mutation in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene, Prothrombin (Factor II) G20210A mutation analysis and Factor V Leiden mutation analysis with reflex to Factor V HR2 if the Factor V Leiden testing is positive. Individuals with multiple thrombophilic mutations develop venous thromboembolism at a younger age and are at higher risk for recurrent thrombosis than those with a single defect.
The panel may be ordered as is or the tests may be ordered individually.
Indications for Testing:
- Deep vein thrombosis
- Pulmonary embolism
- Stroke
- Superficial venous thrombosis, phlebitis or thrombophlebitis
- History of thromboembolism
- Premature cardiovascular disease
- Peripheral vascular artery disease
- Acute myocardial infarction
- Personal history of 2 or more blood-clotting incidents
- Family history of blood clots, early stroke or premature vascular artery disease
- Unexplained early-onset severe preeclampsia, placental abruption, or significant intrauterine growth retardation
- Recurrent unexplained first-trimester losses
Sample Requirements: 5 mL whole blood in purple top (EDTA) tube
Sample Handling: Blood samples stored overnight should be refrigerated or kept cold. Blood samples should never be frozen. Specimens being sent from outside facilities should be packaged with a cold pack according to standard medical safety practices. The specimen should be shipped by overnight priority [scheduled to arrive by Friday AM at the latest].
Shipping Address: Center for Human Genetics Laboratory
10524 Euclid Ave, 6th Floor
Cleveland, OH 44106
216-983-1134
For local samples, please call the Center for Human Genetics Laboratory (216-983-1134) to arrange for sample pick-up.
Turn Around Time: 3-9 days
Cost/CPT codes: $315.70 / 83890, 83892(x6), 83896(x12), 83912(x3)