Trial
Name
This research study is designed to learn whether different anti-HIV medication ("HAART") combinations work equally well in participants who have never taken anti-HIV medications before.
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The Addiction Recovery Services of University Hospitals Case Medical Center is conducting clinical research on the treatment of Alcohol Dependence in adults with Bipolar I Disorder, a mood disorder that affects more than
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ALS is a devastating disease that eventually affects respiratory function. Treatment options for respiratory function are limited to no treatment, non-invasive or invasive ventilation. Stimulation of the Diaphragm in Amyotrophic Lateral Sclerosis is an investigation of a diaphragm pacing system
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This research study will examine how atomoxetine (Scrattera) in the treatment of ADHD in adults and how ADHD affects family functioning. Eligible participants who meet screening criteria will be closely monitored with frequent clinical visits with a physician
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The purpose of this research study is to learn more about how to care for women who are at increased genetic risk of ovarian cancer.
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This study is designed to determine whether there is an increased incidence of Barrett's esophagus or esophageal cancer in the relatives of persons with Barrett's esophagus or esophageal cancer.
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This research study compares lithium and valproate (Depakote) in the treatment of older adults with bipolar manic (high mood) and hypomanic episodes (slightly high mood)
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A Double-Blind Randomized Trial of Pyridoxine versus Placebo for the Prevention of Doxil-Related Palmar-Plantar Erythrodysesthesia (Hand-Foot Syndrome)
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A Phase II Study of GW572016 and Tamoxifen in Patients with Metastatic Breast Cancer Resistant to Single Agent Tamoxifen
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Impact of Treatment with Taxane or Platinum-Containing Regimens on Peripheral Nerve Functioning in Older Cancer Patients with Diabetes: An Exploratory Study
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A Phase IB Study in Patients with Metastatic Colorectal Cancer to Evaluate Pharmacodynamic Effects of Erlotinib and Safety and Efficacy of Erlotinib in Combination with modified FOLFOX6 (mFOLFOX6) and Beracizumab.
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Dose-Dense and Dose-Intense Alternating Irinotecan/Capecitabine and Oxaliplatin/Capecitabine: Phase I in Solid Tumors and Phase II with Bevacizumab as First-Line Therapy of Advanced Colorectal Cancer
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A Multicenter, Open Label, Noncomparative Phase I-II Clinical and Pharmacokinetic Study of Oral PD0325901 in Patients with Advanced Cancer
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Phase II Study of Oxaliplatin, Irinotecan, and Capecitabine in Advanced Gastric/Gastroesophageal Junction Carcinoma
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A Randomized Phase III Study Comparing 5-FU, Leucovorin and Oxaliplatin versus 5-FU, Leucovorin, and Oxaliplatin versus 5-FU, Leucovorin, Oxaliplatin and Bevacizumab in Patients with Stage II Colon Cancer at High Risk for Recurrence to Determine Prospectively the Prognostic Value of Molecular Markers
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This research study will evaluate the usefulness of urodynamic testing which is a test that measures bladder function.
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Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastrointestinal Adenocarcinoma
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A Phase III Randomized Double-blind Study of Adjuvant STI571 (Gleevec) Versus Placebo in Patients Following the Resection of Primary Gastrointestinal Stromal Tumor (GIST)
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A Dose Escalation Study of OncoGel® Treatment as an Adjunctive Therapy to External Beam Radiation in Patients with Inoperable Esophageal Cancer
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This research study is designed to reduce certain side effects that may be caused by a specific type of cancer treatment (Doxil).
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This research study is designed to compare two treatments for ovarian, fallopian tube or peritoneal cancers.
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A Randomized, Phase II Study of TNFerade Biologic with 5-FU and Radiation Therapy for First-Line Treatment of Unresectable Locally Advanced Pancreatic Cancer
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Pilot Study of Changes in Fat-Free Mass in Patients with Pancreatic Carcinoma
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Master Protocol for Pharmacogenetic and Genomic Studies
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Intermediate Androgen Deprivation in Patients With Stage D2 Prostate
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Cytokine Genotypes and Risk of Depression Syndromes in Patients Undergoing Radiotherapy for Prostate Cancer, and Efficacy of Treatment with Bupropion
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A Multicenter, open-label, randomized, Phase III Trial comparing Immediate Adjuvant Hormonal Therapy (ELIGARD®- leuprolide acetate) in combination with TAXOTERE® (docetaxel) administered every three weeks versus Hormonal Therapy alone versus Deferred Therapy followed by the
same therapeutic options in patients with Prostate Cancer at High Risk of Relapse after Radical Prostatectomy
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A Randomized, Double Blind Phase III Trial of Adjuvant Sunitinib versus Sorafenib versus Placebo in Patients with Resected Renal Cell Carcinoma
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This research study is designed to determine whether combining the drug Tirapazamine with Cisplatin during radiation therapy increases the length of time that patients with cancer of the cervix live without their cancer coming back compared to patients who receive Cisplatin and radiation therapy without receiving Tirapazamine.
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This research study is designed to test the drug Celecoxib in the treatment of cervical intraepithelial neoplasia (CIN 3-a precancerous lesion of the cervix).
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This research study is designed to help identify how to best measure side effects of chemotherapy related to hearing.
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The Colon Cancer Sibling Study is a family research study funded by the National Cancer Institute to identify new genes related to the development of colon polyps or colon cancer.
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This research study is designed to look at the safety and effectiveness of an oral study drug called AST-120 in participants who have Crohn's disease with a draining fistula
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This research study will examine the use of escitalopram (Lexapro) in the treatment of children suffering from depression.
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This research study is designed to determine whether the study medication will slow the progress of kidney disease in individuals with Type II Diabetes.
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This research study is designed to determine the effectiveness of adding stereotactic radiosurgery, with the help of a specialized Magnetic Resonance (MR) scan, to standard radiation therapy for participants with a type of brain tumor called glioblastoma.
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The Skin Study Center of the Department of Dermatology is doing basic research into the cellular causes of hair loss (alopecia).
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FUSION II is a research study for patients who have recently been hospitalized with heart failure. The research study is designed to determine whether a medicine called nesiritide (Natrecor®)
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The goal of this research study is to find out if the drug nicardipine (Cardene®) can be used for the treatment of high blood pressure that occurs after people have suffered a stroke due to sudden bleeding in their brain.
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The HIV Metabolic Research Center is conducting the HIV Lipoatrophy Study to understand how HIV infected adults can avoid the disfigurement of fat loss.
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This research study is designed to learn more about preventing atherosclerosis (hardening of the arteries) in children and young adults with Lupus.
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The Department of Dermatology is conducting an investigational study for patients with lupus that manifests in the skin and affects specific cells in the immune system.
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For nearly 20 years, University Memory and Aging Center researchers have been studying why some people develop problems with memory, thinking, and activities of daily living as they age, while others retain normal memories.
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This research study is designed to determine whether thymectomy (surgical removal of the thymus) helps participants with myasthenia gravis (MG) get better compared to using only medications like prednisone that suppress the immune system.
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This research study is designed for children and adolescents who have experienced a trauma (e.g. sexual/physical abuse, violence, a car accident) and then developed posttraumatic stress disorder (PTSD).
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This clinical research study will evaluate whether an FDA approved medication for enlarged prostate will improve sexual function.
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The Department of Dermatology is conducting research for adults with moderate to severe plaque psoriasis to evaluate the safety and effectiveness of a medication that is a subcutaneous injection (just underneath the skin).
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The Department of Dermatology is conducting a research study to evaluate the effects of a cream applied to the skin for the treatment of psoriasis.
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The Department of Dermatology is conducting research for adults with moderate to severe plaque psoriasis to evaluate the safety and effectiveness of a medication that is a subcutaneous injection (just underneath the skin).
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The Skin Study Center in the Department of Dermatology is conducting a research study for adults with Actinic keratoses (AK), Bowen's disease, Squamous cell carcinoma, Basal cell carcinoma, or Mycosis fungoides (MF stages IA, IIA, IB, or IIB).
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The Skin Study Center of the Department of Dermatology is doing basic research into the cellular causes of psoriasis.
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"Electrical activation of the diaphragm for ventilatory assist" is a clinical research study investigating a new diaphragm pacing system in quadriplegic patients who require a mechanism ventilator.
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The Neurological Institute Clinical Trials Unit is conducting a research study to find out if treatment with either aspirin alone or aspirin and Plavix® help to prevent another stroke in people who recently suffered a "lacunar stroke&qu
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This research study is designed to compare two treatments for inidividuals who have a Patent Foramen Ovale (PFO; an opening in the heart) and who had a recent stroke.
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Standard rehabilitation does not restore normal, safe walking to many stroke survivors. Functional Neuromuscular Stimulation (FNS), using intramuscular electrodes (applying electrical stimulation to the muscles), has been shown to help retrain walking patterns for people who have had a stroke more than one year ago.
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This research study is designed to improve arm function after stroke. Two types of treatment will be offered: 1) robotics motor learning (ROB ML); and 2) FNS motor learning (FNS ML).
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The Department of Neurology is conducting a research study to determine whether pioglitazone, a medication used to treat diabetes, may help prevent another stroke in patients who have been diagnosed with insulin resistance and who have already
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The Longitudinal Study of Urea Cycle Disorders (UCDs) will follow individuals with UCDs so that more can be learned about the natural history of all eight forms of the disorder.
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This research study will use blood tests and (optional) ultrasound imaging to help doctors learn more about hormone levels and other aspects of ovarian structure and function before, during, and after chemotherapy.
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A Phase II Study of Faslodex® in Recurrent/Metastatic Endometrial Cancer
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Randomized Phase III Trial of Doxorubicin/Cisplatin/Paclitaxel and G-CSF versus Carboplatin/Paclitaxel in Patients with Stage III and IV or Recurrent Endometrial Cancer
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A Phase II Evaluation of Trastuzumab in Patients with Advanced, Recurrent or Persistent Endometrial Carcinoma with or without Prior Chemotherapy
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A Phase II Trial of ZD1839 (Iressa) in the Treatment of Persistent or Recurrent Endometrial Carcinoma
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Phase I Toxicity Trial of Doxorubicin-Cisplatin followed by Whole Abdominal Irradiation for Advanced Endometrial Carcinoma
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A Phase II Evaluation on Ixabepilone (BMS-247550) in the Treatment of Recurrent or Persistent Endometrial Carcinoma
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A Phase II Study of Triapine and Cisplatin in the Treatment of Recurrent or Persistent Ovarian Carcinoma.
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A Phase II Randomized Trial of BAY-43-9006, a Novel RafKinase Inhibitor, versus BAY 43-9006 plus Paclitaxel/Carboplatin in Women with Recurrent Platinum Sensitive Epithelial Ovarian, Peritoneal or Fallopian Tube Cancer
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A Randomized Study of Tamoxifen versus Thalidomide in Patients with Biochemical Recurrence Only Epithelial Ovarian Cancer, Cancer of the Fallopian Tube, and Primary Peritoneal Carcinoma after First Line Chemotherapy
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A Phase II Randomized Trial of BAY-43-9006, a Novel RafKinase Inhibitor, versus BAY 43-9006 plus Paclitaxel/Carboplatin in Women with Recurrent Platinum Sensitive Epithelial Ovarian, Peritoneal or Fallopian Tube Cancer
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A Randomized Phase III Trial of IV Carboplatin (AUC 6) and Paclitaxel 175 mg/m2 Every 21 Days X 3 Courses Plus Low Dose Paclitaxel 40 mg/m2/wk versus IV Carboplatin (AUC 6) and Paclitaxel 175 mg/m2 Every 21 Days X 3 Courses and Observation in Patient
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A Dose-Escalating Phase I Study with an Expanded Cohort to Assess the Feasibility of Intraperitoneal Carboplatin and Intravenous Paclitaxel in Patients with Previously Untreated Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Carcinoma
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A Phase I Trial of Intravenous Paclitaxel Intraperitoneal Carboplatin and Intraperitoneal Paclitaxel or Intravenous Docetaxel, Intraperitoneal Carboplatin and Intraperitoneal Paclitaxel in Patients with Previously Untreated Epithelial Ovarian Carcinoma, Fallopian Tube or Primary Peritoneal Carcinoma
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A Phase I Study of Paclitaxel, Carboplatin and Increasing Doses of Doxil in Untreated Ovarian, Peritoneal and Tubal Carcinoma
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A Randomized Phase III Trial of Maintenance Chemotherapy Comparing 12 Monthly Cycles of Single Agent Paclitaxel or Xyotax (CT-2103) versus No Treatment until Documented Relapse in Women with Advanced Ovarian or Primary Peritoneal Cancer Who Achieve a Complete Clinical Response to Primary Platinum/Taxane Chemotherapy
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A Two-Part Phase I/II Study of Extended Field External Irradiation and Intracavity Brachytherapy Combined with Chemotherapy (weekly cisplatin) and Amifostine (weekly cisplatin and amifostine) in Carcinoma of the Cervix with Positive Para-Aortic or High Common Iliac Lymph Nodes
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A Randomized Phase III Trial of Paclitaxel plus Cisplatin versus Vinorelbine plus Cisplatin versus Gemcitabine plus Cisplatin versus Topotecan plus Cisplatin in Stage IVB, Recurrent or Persistent Carcinoma of the Cervix
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A Randomized Phase III Trial of Weekly Parenteral Methotrexate versus "Pulsed" Dactinomycin as Primary Management for Low Risk Gestational Trophoblastic Neoplasia
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Impact of Treatment with Taxane or Platinum-Containing Regimens on Peripheral Nerve Functioning in Older Cancer Patients with Diabetes: An Exploratory Study
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A Phase II Study of Bevacizumab in Combination with Docetaxel and Radiation in Locally Advanced Squamous Cell Cancer of the Head and Neck.
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Phase III Randomized, Placebo-Controlled, Trial of Docetaxel versus Docetaxel plus ZD1839 (Iressa, Gefitinib) in Performance Status 2 or Previously Treated Patients with Recurrent or Metastatic Head and Neck Cancer
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Phase II Trial of BAY 43-9006 in Patients with Advanced Anaplastic Carcinoma of the Thyroid.
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A Phase II Trial of Imatinib Mesylate (Gleevec) in Patients with HIV-Related
Kaposi's Sarcoma
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Phase I and Pharmacodynamic Study of SB-715992 in Acute Leukemias
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A Phase II Trial of Combination Therapy with Thalidomide, Arsenic Trioxide, Dexamethasone, and Ascorbic Acid (TADA) in Patients with Chronic Idiopathic Myelofibrosis or Overlap Myelodysplastic/Myeloproliferative Disorders
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A Phase I Trial of PS-341 and Fludarabine for Relapsed and Refractory Indolent Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia
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A Phase II Study of PS-341 in Low Grade Lymphoproliferative Disorders
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Phase III Randomized Trial of Autologous and Allogeneic Bone Marrow Transplantation versus Intensive Conventional Chemotherapy I Acute Lympoblastic Leukemia in First Remission
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A Phase III Randomized Study of Farnesyl Transferase Inhibitor R115777 in Acute Myeloid Leukemia (AML) Patients in Second or Subsequent Remission or in Remission After Primary Induction Failure
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Ancillary Laboratory Protocol for Collecting Diagnostic Material on Patients Considered for ECOG Treatment Trials for Leukemia or Related Hematologic Disorders
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A Randomized, Multicenter, Open-Label, Modified Dose-Ascension, Parallel Study of the Safety, Tolerability, and Efficacy of Oral SCIO-469 in Patients with Myelodysplastic Syndromes (MDS)
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Randomized Phase III Trial Comparing Two Different Rituximab Dosing Regimens for Patients with Low Tumor Burden Indolent Non-Hodgkin's Lymphoma
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Phase III, Randomized, Double Blind Placebo-Controlled Trial of FavID and GM-CSF versus Placebo and GM-CSF Following Rituximab in Subjects with Follicular B-Cell Non-Hodgkin’s Lymphoma
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Phase II Trial of FavId (Patient-Specific Idiotype/KLH) and GM-CSF in Subjects Who Demonstrated Progressive Disease and Did Not Receive FAVID on Study FVID 1404
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A Phase II Study of Bryostatin 1 and Vincristine in Patients with Low or Intermediate Grade Non-Hodgkin’s Lymphoma Progressing or Relapsing After a Prior Autologous Bone Marrow or Stem Cell Transplant
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A Phase II Study of Bryostatin 1 and Vincristine in Patients with Low or Intermediate Grade Non-Hodgkin’s Lymphoma Progressing or Relapsing After a Prior Autologous Bone Marrow or Stem Cell Transplant
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Prognostic Significance of Early Positron Emission Tomography (PET) with Fluorine-18 Fluorodeoxyglucose ([18F] FDG) in Intermediate and High Grade Non-Hodgkin's Lymphoma
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Phase II Trial of FavId (Patient-Specific Idiotype/KLH) and GM-CSF in Subjects Who Demonstrated Progressive Disease and Did Not Receive FAVID on Study FVID 1404
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A Phase II Study of Bryostatin 1 and Vincristine in Patients with Low or Intermediate Grade Non-Hodgkin’s Lymphoma Progressing or Relapsing After a Prior Autologous Bone Marrow or Stem Cell Transplant
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A Phase II Study of PS-341 in Low Grade Lymphoproliferative Disorders
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Randomized Study of Four Weeks High Dose Interferon Alpha 2B in Stage IIA Melanoma
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A Double-blind, Randomized, Placebo-Controlled Phase III Trial of Carboplatin, Paclitaxel and BAY 43-9006 versus Carboplatin, Paclitaxel and Placebo in Patients with Unresectable Locally Advanced or Stage IV Melanoma
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A Double-blind, Randomized, Placebo-Controlled Phase III Trial of Carboplatin, Paclitaxel and BAY 43-9006 versus Carboplatin, Paclitaxel and Placebo in Patients with Unresectable Locally Advanced or Stage IV Melanoma
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Phase II Trial of Interferon-Beta in Patients with Metstatic Cutaneous Melanoma and Metastatic Ocular Melanoma
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A Phase II Study of Systemic High-Dose Methotrexate for the Treatment of Glioblastoma Multiforme (GBM) in Newly Diagnosed Patients with Measurable Disease
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A Phase I/III Randomized Study of Radiation Therapy and Temozolomide Versus Radiation Therapy and BCNU for Anaplastic Astrocytoma
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Phase II Trial of Conventional Radiotherapy with Stereotactic Radiosurgery to High Risk Tumor Regions as Determined by Functional Imaging in Patients with Glioblastoma Multiforme
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11C Topotecan PET Imaging
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Classification of Acute Lymphoblastic Leukemia
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High Risk B-Precursor Acute Lymphoblastic Leukemia, A Phase III Group-Wide Study
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Phase III Randomized Study of Chimeric Anti-GD2 in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue
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A Phase II/III Study of Immunomodulation after High Dose Myeloablative Therapy with Autologous Stem Cell Rescue for Refractory/Relapsed Hodgkin’s Disease
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A Phase III Trial of Treatment of Advanced Stage Anaplastic Large Cell Lymphoma (ALCL) with Standard APO (Doxorubicin, Prednisone, Vincristine versus Consolidation with a Regimen including Vinblastine
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A Phase III Group-Wide Study of Dose-Intensive Response-Based Chemotherapy and Radiation Therapy for Children and Adolescents with Newly Diagnosed Intermediate Risk Hodgkin’s Disease
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Vincristine, Dactinomycin and Lower Doses of Cyclophosphamide with or without Radiation Therapy for Patients with Newly Diagnosed Low Risk Embryonal/Botryoid/Spindle Cell Rhabdomyosarcoma
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A Phase II Study of Oxaliplatin in Children with Recurrent Solid Tumors
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A Phase II Study of Temozolomide in the Treatment of Children with High Grade Glioma or Diffuse Intrinsic Pontine Gliomas
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A Phase II Study of Concurrent Radiation and Temozolomide Followed by Temozolomide and Lomustine (CCNU) in the Treatment of Children with High Grade Glioma
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Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than 10 Years Old
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European Ewing Tumor Working Initiative of National Groups Ewing Tumor Studies 1999 (EURO-E.W.I.N.G. 99)
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Intergroup Protocol for Treatment of Children with Hepatoblastoma
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A Phase II Study of Sulindac and Tamoxifen in Patients with Desmoid Tumors that are Recurrent or Not Amenable to Standard Therapy
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A Randomized Double Blind Placebo Controlled Trial to Assess the Efficacy of Traumeel S for the Prevention and Treatment of Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation
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A Groupwide Biology and Banking Study for Ewing Sarcoma
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Neuroblastoma Biology Studies
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A COG Soft Tissue Sarcoma Biology and Banking Protocol
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A Children’s Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors
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A Children’s Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens
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A Phase I Study of Bevacizumab in Combination with SU11248
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A Phase IB Study in Patients with Metastatic Colorectal Cancer to Evaluate Pharmacodynamic Effects of Erlotinib and Safety and Efficacy of Erlotinib in Combination with modified FOLFOX6 (mFOLFOX6) and Beracizumab.
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Phase I Clinical Trial Using Topical Silicon Phthalocyanine (Pc 4) Photodynamic Therapy (PDT) for the Treatment of Pre-Malignant and Malignant Skin Conditions
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Phase I Trial of Daily Lenalidomide (CC-5013, Revlimid™) and Docetaxel Given Every Three Weeks in Patients with Advanced Solid Tumors.
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A Phase I Pharmacokinetic Study of Epothilone B Analogue BMS-247550 (NSC-710428D) in Patients with Advanced Malignancies and Varying Levels of Liver Dysfunction
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An Open Label, Phase Ib Roll-Over Study to Assess the Long-Term Safety Profile of Lapatinib in Cancer Patients
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A Phase I Pharmacokinetic Study of PS-341 in Patients with Advanced Malignancies and Varying Degrees of Renal Dysfunction for the CTEP-Sponsored Organ Dysfunction Working Group
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Mutant MGM Gene Transfer Into Human Hematopoietic Progenitors to Protect Hematopoiesis During O6-Benzylguanine (BG) and BCNU Therapy of Advanced Solid Tumors
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Phase I Dose Escalation Study of Oral SKI-606 in Subjects with Advanced Malignant Solid Tumors
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Phase I and Pharmacodynamic Study of SB-715992 in Acute Leukemias
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11C Topotecan PET Imaging
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A Multicenter Phase II study of Sorafenib (BAY43-9006) in Non-GIST Sarcomas
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Phase III Chemoprevention Trial of Selenium Supplementation in Persons with Resected Stage I Non-Small Cell Lung Cancer
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A Phase II Trial of Induction Chemoradiotherapy with Cisplatin/Etoposide Followed by Surgical Resection, Followed by Docetaxel, for Non-Small Cell Lung Cancer Involving the Superior Sulcus (Pancoast Tumors)
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A Phase I/II, Open- Label, Multicenter Study of Single Agent PT-523 in the Treatment of Relapsed or Refractory Non-Small Cell Lung Cancer (NSCLC)
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A Phase II Study of HKI-272 in Subjects with Advanced Non-Small Cell Lung Cancer
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A Phase III, Multicenter, Placebo-Controlled, Double Blind, Randomized Clinical Trial to Evaluate the Efficacy of Bevacizumab in Combination with Tarceva™ (Erlotinib) Compared with Tarceva Alone for Treatment of Advanced Non-Small Cell Lung Cancer
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A Double blind Phase II Study of BAY 43-9006 in Patients with Nonsmall Cell Lung Cancer Who Have Failed at Least Two prior Chemotherapy Regimens
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Interferon Alpha (NSC#377523) Plus 13-Cis-Retinoic Acid Modulation of BCL-2 Plus Paclitaxel for Recurrent Small Cell Lung Cancer (SCLC)
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Phase II Trial of XL119 (Rebeccamycin Analogue) in Relapsed Sensitive Small Cell Lung Cancer
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Impact of Treatment with Taxane or Platinum-Containing Regimens on Peripheral Nerve Functioning in Older Cancer Patients with Diabetes: An Exploratory Study
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A Pilot Study of the Safety and Feasibility of Multiple Umbilical Cord Blood (UCB) Unit Transplants Following Non-Myeloablative Conditioning Regimens in Paitients with Hematologic Malignancies or Severe Aplastic Anemia
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A Pilot Study of Unrelated Umbilical Cord Blood Transplantation in Patients with High Risk Malignancies
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A Randomized Phase III Trial comparing Early High Dose Chemoradiotherapy and an Autologous Stem Cell Transplant to Conventional Dose CHOP Chemotherapy (with Possible Late Autologous Stem Cell Transplant) for Patients with Diffuse Aggressive Non-Hodgkin's Lymphoma in the High Intermediate and High Risk International Classification Prognostic Groups
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Study of Reduced Intensity (Nonmyeloablative) Allogenic Bone Marrow Transplantation for the Treatment of Relapsed Non-Hodgkin’s and Hodgkin’s Lymphoma
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A Single Arm, Multicenter Phase II Trial of Transplants of HLA-Matched, CD34+ Enriched, T cell Depleted Peripheral Blood Stem Cells (PBSC) Isolated by the CliniMACS System in the Treatment of Patients with AML in First or Second Morphologic Complete
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Phase III Randomized Trial of Autologous and Allogeneic Bone Marrow Transplantation versus Intensive Conventional Chemotherapy in Acute Lymphoblastic Leukemia in First Remission.
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A Pilot Study of Unrelated Umbilical Cord Blood Transplantation in Patients with High Risk Malignancies
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Hematopoietic Stem Cell Transplantation Using Bone Marrow or Peripheral Blood Stem Cells from Matched Unrelated Donors
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A Trial of Tandem Autologous Stem Cell Transplants Plus or Minus Post Second Autologous Transplant Maintenance therapy Versus Single Autologous Stem Cell Transplant Followed by Matched Sibling Non-Myeloablative Allogeneic Stem Cell Transplant for Patients with Multiple Myeloma
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A Phase III Randomized, Multicenter Trial Comparing G-CSF Mobilized Peripheral Blood Stem Cell (PBSC) with Marrow Transplantation from HLA Compatible Unrelated Donors
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Donor Mesenchymal Stem Cell (MSC) Infusion For Treatment of Graft Versus Host Disease: A Phase I Trial
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Initial Systemic Treatment of Acute GVHD: A Phase II Randomized Trial Evaluating Etanercept, Mycophenolate Mofetil (MMF), Denileukin Diftitox (Ontak), and Pentostatin in Combination with Corticosteroids
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Randomized, Phase III Study for the Treatment of Newly Diagnosed Disseminated Lymphoblastic Lymphoma or Localized Lymphoblastic Lymphoma
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Phase III Chemoprevention Trial of Selenium Supplementation in Persons with Resected Stage I Non-Small Cell Lung Cancer
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A Phase II Trial of Induction Chemoradiotherapy with Cisplatin/Etoposide Followed by Surgical Resection, Followed by Docetaxel, for Non-Small Cell Lung Cancer Involving the Superior Sulcus (Pancoast Tumors)
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Master Protocol for Pharmacogenetic and Genomic Studies
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Phase III Chemoprevention Trial of Selenium Supplementation in Persons with Resected Stage I Non-Small Cell Lung Cancer
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NSABP B-37: A Randomized Clinical Trial of Adjuvant Chemotherapy for Radically Resected Loco-Regional Relapse of Breast Cancer.
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IBCSG 24-02: A Phase III Trial Evaluating the Role of Ovarian Function Suppression and the Role of Exemestane as Adjuvant Therapies for Premenopausal Women with Endocrine Responsive Breast Cancer
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S 0230: Phase III Trial of LHRH Analog Administration During Chemotherapy to Reduce Ovarian Failure Following Standard Adjuvant Chemotherapy in Early Stage, Hormone Receptor Negative Breast Cancer
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CALGB 40101: Cyclophosphamide and Doxorubicin (CA) versus Paclitaxel as Adjuvant Therapy for Women with Node-Negative Breast Cancer: A 2x2 Factorial Phase III Randomized Study
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A Randomized Trial Comparing the Safety and Efficacy of Adriamycin and Cyclophosphamide Followed by Taxol (AC – T) to that of Adriamycin and Cyclophosphamide Followed by Taxol plus Herceptin (AC-T) in Node-Positive Breast Cancer Patients who have Tumors that Overexpress HER2.
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A Phase III, Adjuvant Trial Comparing Three Chemotherapy Regimens in Women with Node-Positive Breast Cancer: Docetaxel/Doxorubicin/Cyclophosphamide (TAC); Dose-Dense (DD) Doxorubicin/Cyclophosphamide Followed by DD Paclitaxel (DD AC -P); DD AC Followed by DD Paclitaxel Plus Gemcitabine (DD AC -PG).
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Phase II Study of Low Dose Peginterferon Alfa-2b in Patients with Metastatic Melanoma Over-Expressing Basic Fibroblast Growth Factor
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This research study will evaluate a topical knee patch compared with placebo in treating patients who have OA of the knee.
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This research study will evaluate the safety and efficacy of an injectable drug in the treatment of subjects with rheumatoid arthritis who have an inadequate response to TNF- therapy.
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This research study will evaluate the performance of a Walking Model of Osteoarthritis (OA) while walking on a treadmill.
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Urologic Oncology and Minimally Invasive Therapies Database for UHHS Faculty
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Infected or contaminated hernias
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A Randomized trial of Vitamin D and Calcium therapy versus Placebo and Calcium in patients 60 years or older with Heart Failure from any cause.
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AREDS 2 - Age-Related Eye Disease Study 2: An investigative study of the effects of oral supplements of lutein/zeaxanthin and omega-3 fatty acids for the treatment of dry AMD.
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The purpose of this research is to determine if ranibizumab alone or with laser photocoagulation is more efficacious than photocoagulation alone for the treatment of Diabetic Macular Edema.
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The purpose of this research is to determine if Intravitreal triamcinolone acetonide or intravitreal ranibizumab will reduce the magnitude of visual acuity loss in patients with Diabetic Macular Edema.
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The Mood Disorders Program of University Hospitals Case Medical Center is conducting clinical research on the treatment of symptoms related to Generalized Anxiety Disorder and Bipolar Disorder with or without Substance Use Disorder.
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The Mood Disorders Program of University Hospitals Case Medical Center is conducting clinical research on the treatment of symptoms related to Major Depressive Disorder with Generalized Anxiety.
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The Mood Disorders Program of University Hospitals Case Medical Center is conducting an observational study related to Treatment Resistant Depression (TRD), which is defined as being in the current episode of depression for the past 2 years or longer, and having failed trials of at least 4 medications for depression.
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The Mood Disorders Program of University Hospitals Case Medical Center is building a Registry to collect demographic information on a wide cross section of patients with a mood disorder.
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The Mood Disorders Program of University Hospitals Case Medical Center is conducting clinical research on the treatment of symptoms related to Bipolar Disorder, a mood disorder that affects more than four million people in the United States.
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The Mood Disorders Research Program of University Hospitals Case Medical Center is conducting clinical research on the treatment of symptoms related to Major Depressive Disorder.
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The Mood Disorders Program of University Hospitals Case Medical Center is building a Registry to collect demographic information on a wide cross section of patients with a mood disorder.
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The study is a randomized, parallel group, unblinded, multicenter study that compares two approaches [home-based, portable monitoring (PM) versus attended, laboratory-based polysomnography (PSG) (Lab)] in adults, at least 18 years of age, with a moderate to high probability of obstructive sleep apnea (OSA) and who have been referred to sleep medicine specialists at AASM-accredited sleep centers for evaluation and/or management.
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Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist
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A Multi-Center, Single-Blind, Randomized Study Comparing Thymectomy to No Thymectomy in Non-Thymomatous Myasthenia Gravis (MG) Patients Receiving Prednisone
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ARIES-3: A Phase 3, Long-term, Open-label, Multicenter Safety and Efficacy Study of Ambrisentan in Subjects with Pulmonary Hypertension
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REVEAL Registry (Registry to EValuate Early and Long-Term PAH Disease)
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The purpose of this research study is to understand how immune responses within the lung protect against respiratory infection with Mycobacterium tuberculosis, the organism that causes tuberculosis (Tb).
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The purpose of this research study is to clarify the cause of the multi-organ inflammatory disease sarcoidosis.
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