Female Testosterone Patch Restores Sexual Desire in Post-Menopausal Women

Female Testosterone Patch Restores Sexual Desire in Post-Menopausal Women
CLEVELAND -- A promising new treatment for women suffering from dwindling sexual desire involves the delivery of testosterone through a skin patch worn on the abdomen. The investigational testosterone patch, known as Intrinsa, was studied at University Hospitals of Cleveland's MacDonald Women's Hospital.

"The testosterone patch definitely enhanced and renewed the relationship with my partner, now going on 19 years," says Jean Toth, 56, of Eastlake, Ohio. "The patch has affected me overall -- it has helped to improve my life. I look better, I feel better and I take more pride in myself." Four years ago, Ms. Toth noticed a decline in her sexual desire. Last year, she volunteered for the clinical trial testing the patch and noticed immediate results. "I just knew I wasn't on the placebo."

The 24-week study of Intrinsa, the investigational patch developed by Proctor & Gamble, involved 533 postmenopausal women at 50 medical centers. Results indicated dramatically improved sexual desire and satisfaction.
The women had been diagnosed with Hypoactive Sexual Desire Disorder. Decreased sexual desire and satisfaction is a common consequence of total hysterectomy or natural menopause. Lack of sexual desire can lead to feelings of unhappiness, frustration, and can add strain to relationships.

"Research has found that about one in three surgically menopausal women and one in 10 naturally menopausal women express sexual desire complaints, which often leads to personal distress and relationship issues," says Sheryl Kingsberg, PhD, clinical psychologist at University Hospitals MacDonald Women's Hospital, and one of the study's lead investigators. "The patch Intrinsa is for postmenopausal women who have lost testosterone directly related to their loss of ovarian function. The patch actually restores sexual desire back to the pretreatment levels women had before."

Widely known as a male sex hormone, testosterone is produced naturally in female ovaries and adrenal glands. Testosterone has been proven to have a direct connection to female sexual desire and function.

The women involved in the study at University Hospitals had had one or more ovaries removed and were in stable, monogamous relationships. Each patient had been receiving estrogen therapy before the study began. Those women who were using the testosterone patch for 24 weeks experienced significant improvements in arousal, orgasm and self-image.

If approved by the Food and Drug Administration, the female testosterone patch would be the first therapy to be specifically authorized to improve sexual desire in women.

Posted on Wednesday, July 07, 2004 (Archive on Wednesday, July 14, 2004)
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